Behavioral functions of locus coeruleus derived from cellular attributes
نویسندگان
چکیده
منابع مشابه
Role of locus coeruleus in attention and behavioral flexibility.
Previous findings have implicated the noradrenergic locus coeruleus (LC) system in functions along the dimension of arousal or attention. It has remained uncertain what role this system has in attention, or what mechanisms may be involved. We review our recent work examining activity of LC neurons in monkeys performing a visual discrimination task that requires focused attention. Results indica...
متن کاملThe human locus coeruleus: computer reconstruction of cellular distribution.
Quantitative neuroanatomical techniques were developed to map the distribution of norepinephrine-containing locus coeruleus (LC) neurons in the adult human brain. These neurons reside in the dorsolateral pontine tegmentum and are identifiable by their neuromelanin pigment content. Five brains, ranging in age from 60 to 104 years, were examined. Outlines of coronal or sagittal sections containin...
متن کاملNorepinephrine and its metabolites are involved in the synthesis of neuromelanin derived from the locus coeruleus
In order to elucidate the chemical structure of black to brown pigments, neuromelanins (NMs), in the substantia nigra (SN) and the locus coeruleus (LC) in the central nervous system of humans and other mammalian species during aging, chemical degradative methods are powerful tools. HPLC analysis after hydroiodic acid hydrolysis detected aminohydroxyphenylethylamines, aminohydroxyphenylacetic ac...
متن کاملThe locus coeruleus and regulation of behavioral flexibility and attention: clinical implications
It has been proposed that the locus coeruleus (LC) regulates nonspecific arousal and thereby may participate in a wide range of functions. Our work indicates that, while the LC may indeed play an important role in arousal, it has more specific effects on behavior and may regulate cortical mechanisms involved in selective attention and task performance. In one study, we recorded impulse activity...
متن کاملOrganization of the Locus Coeruleus-Norepinephrine System
The release of the neurotransmitter norepinephrine throughout the mammalian brain is important for modulating attention, arousal, and cognition during many behaviors. Furthermore, disruption of norepinephrine-mediated signaling is strongly associated with several psychiatric and neurodegenerative disorders in humans, emphasizing the clinical importance of this system. Most of the norepinephrine...
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ژورنال
عنوان ژورنال: Physiological Psychology
سال: 1985
ISSN: 0090-5046
DOI: 10.3758/bf03326513